返回 2008年第31卷第3期 目录

顺铂与草酸铂联合长春瑞滨治疗晚期非小细胞肺癌比较研究

徐敬根，张 静，易 琼1

（双流县第一人民医院肿瘤科，四川双流 610200，1四川大学华西医院肿瘤二科）

摘 要 目的：长春瑞滨联合顺铂化疗是治疗晚期非小细胞肺癌（NSCLC）的主要化疗方案之一，但副反应较重。本研究的目的是比较顺铂（DDP）与草酸铂（L-OHP）联合长春瑞滨NVB组成的化疗方案对晚期非小细胞肺癌的近期疗效和毒副作用。方法：将103例Ⅲ~Ⅳ期NSCLC患者随机分成A组（DDP+NVB/ DDP方案53例）和B组（L-OHP+NVB /L-OHP方案50例）21~28d为1周期，化疗2~3个周期，评价疗效。结果：A组有效率41.5%，B组有效率46.0%。两组剂量限制性毒性反应均为骨髓抑制、胃肠道反应和静脉炎。A组Ⅲ、Ⅳ度白细胞下降发生率为41.5%，B组为12.0%（Ｐ<０.０５）；Ａ组Ⅲ~Ⅳ度恶心呕吐发生率为43.4%，B组为4.0%,两组比较有统计学意义（Ｐ<０.０５），但均可耐受。结论：DDP方案和Ｌ－ＯHP方案治疗NSCLC疗效相近,毒性反应均可耐受,但L-ＯＨＰ的毒副反应均较轻，值得推荐。

关键词 肺肿瘤化疗；长春瑞滨；顺铂；草酸铂

COMPARISION OF SHORT-TERM EFFICIENCY BETWEEN THE CIS-PLATINUM REGIMEN AND THE OXALIPLATIN REGIMEN IN THE TREATMENT OF ADVANCED NON-SMALL-CELL LUNG CANCER

Xu Jinggen,et al

Department of Oncology ,the First Hospital of Shuangliu County

Abstract Objective：To compare the short-term efficiency, toxicity and side effect between Vinorelbine plus Cis-platinum(DDP regimen) and vinorelbine plus Oxaliplatin(L-OHP regimen) in the treatment of non-small-cell lung cancer(NSCLC). Methods:One hundred and three patients with Ⅲ~Ⅳstage NSCLC were divided into group A(53 cases) received DDP+NVB regimen chemotherapy，group B(50 cases) received L-OHP+NVB regimen chemotherapy.Results：The effective rates were 41.5% and 46.0% respectively for DDP and L-OHP regimen (P＞0.05).The dose limiting toxicity was myelosuppresion which was seen in both groups. Gastrointestinal side-effect and local phlebitis were also observed.The rates of grade Ⅲ、Ⅳleukopenia were 41.5%(group A) and 12.0%(group B) and gastrointestinal side-effect were 43.4%(group A) and 4.0%(group B) ,with statistical difference between the two groups(P<0.05).Conclusion：The therapeutic efficiency of DDP regimen was similarly to that of L-OHP regimen,but the myelosuppression and gastrointestinal side-effect of L-OHP regimen were milder than that of DDP regimen.

Key words Lung neoplasms；Chemotherapy Vinorelbine Cis-platinum Oxaliplatin