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急性冠脉综合征冠脉病变严重性与纤溶及炎症指标的相关性研究

薛 莉，潘金生，刘应才，黄维义

（泸州医学院附属医院心内科，四川泸州 646000）

摘 要 目的:探讨急性冠脉综合征冠脉病变严重性与纤溶及炎症指标的相关性。方法:选择急性冠脉综合征患者48例（ACS组），对照组32例对全部受试者进行冠脉造影，对冠脉狭窄评分，测定外周静脉血D-D、PAI、TNF-α和HS-CRP的水平并进行比较，并对冠脉狭窄评分与纤溶及炎症指标进行相关分析。结果:ACS组D-D、PAI、TNF-α和HS-CRP的水平均高于对照组，有显著性差异（P<0.05）；D-D、PAI、TNF-α和HS-CRP的水平与ACS冠脉病变分数之间呈线性相关关系（r介于0.521~0.774之间）。结论：纤溶及炎症指标的水平可以反映急性冠脉综合征患者冠脉病变的严重性。

关键词 急性冠脉综合征；纤溶；炎症

ANALYSIS OF THE RELATIONSHIP OF FIBRINOLYTIC SYSTEM AND INFLAMMATION TO CORONARY STENOSIS SEVERITY IN ACUTE CORONARY SYNDROME PATIENTS

Xue Li,et al

Department of Cardiology,the Affiliated Hospital of Luzhou Medical College

Abstract Objective: To investigate the relationship of fibrinolytic system and inflammation to coronary stenosis severity in patients with acute coronary syndrome(ACS).Methods: The patients with ACS(n=48) and suspectable coronary heart disease(the control,n=32) were operated on selective coronary arteriography and coronary stenosis scores were calculated by accumulative total integration. Plasma concentrations of D-Dimer(D-D),plasminogen activator inhibitor(PAI), high sensitivity C reactive protein(HS-CRP), tumor necrosis factor-α(TNF-α) were determined in patients with ACS and control group.Results:Plasma concentrations of D-D, PAI, TNF-α and HS- CRP were significantly higher in ACS than that in the controls（P<0.05~0.01）. Plasma concentrations of HS- CRP, TNF-α,D-D and PAI were correlated with ACS and had a linear positive correlation with the scores of stenosis coronary vessels(r=0.521-0.774). Conclusion: Plasma levels of HS- CRP, TNF-α,D-D and PAI may reflect coronary stenosis severity in patients with acute coronary syndrome.

Key words Acute Coronary Syndrome ;Fibrinolytic system;Inflammation