返回 2007年第30卷第5期 目录

雌激素改善皮瓣组织损伤的实验性研究

徐瑞生，葛建华，雷玉凯，鲁晓波

（泸州医学院附属医院骨关节外科，四川泸州 646000)

摘 要 目的：研究不同剂量雌激素对皮瓣组织损伤及存活面积的影响，并探讨其可能的作用机制。方法：新西兰白兔30只，随机分为A、B、O三组，O组为对照组。在兔背作超长型皮瓣1个，皮瓣蒂部注射雌激素，三组间剂量不同。术后分别检测皮瓣MDA(丙二醛)、NEU(中性粒细胞)计数、皮瓣存活面积S等指标。结果：①A组、B组皮瓣存活面积较O组增加，MDA、NEU较O组减低。②皮瓣存活面积S与血清MDA含量、皮瓣NEU计数之间呈负相关。结论： ①雌激素注射处理可降低皮瓣MDA含量、减少NEU浸润。②雌激素注射可增加皮瓣存活面积。其机制与雌激素减轻皮瓣损伤有关。

关键词　雌激素；皮瓣存活面积；丙二醛；中性粒细胞浸润;缺血再灌注损伤

 

EXPERIMENTAL STUDY OF ESTROGEN DECREASING FLAP INJURY

Xu Ruisheng，et al

Department of Orthopaedics，The Affiliated Hospital of Luzhou Medical College

Abstract Objective ：To study the effects of estrogen on tissue injury and survival of skin flap .Methods： Thirty rabbits were divided radomly into three groups. A random pattern flap was made on every rabbit's back. Group A and B received different doses of subdermal estrogen injection.Group O ,the control, received no estrogen. Postoperation, MDA, NEU and the survival area of every flap were defected. Results:①In Group A and B , the flap survival area increased and the MDA content and neutrophil counts decreased compared with group O.②The survival area of skin flap was negatively correlated to MDA and NEU.Conclusions:①Estrogen injection can decrease MDA content and Neutrophil counts of flap.②Estrogen injection can increase the survival area of skin flap, because it may decrease the ischemia-reperfusion injury of flap.

Key words Estrogen；Flap survival；Malondialdehyde；Neutrophils infiltration；Ischemia-reperfusion injury