返回 2007年第30卷第5期 目录

氧化型染发剂对豚鼠输卵管的作用

刘　杰，陈 丽，苏红卫

（泸州医学院公共卫生系，四川泸州　646000）

摘 要 目的：了解氧化型染发剂对豚鼠输卵管的慢性毒性作用。方法：将豚鼠随机分为对照组、染发剂浓度为50﹪组、100%三组，将染发剂涂染于豚鼠的皮肤，每周染1次，连续染毒3个月，处死实验动物，作大体解剖观察，并对雌鼠输卵管做常规HE染色，光镜下观察。结果：染发剂对豚鼠体重增加有影响，并导致雌性豚鼠输卵管局部鳞状上皮化生。结论：氧化型染发剂的使用能导致豚鼠输卵管粘膜发生病理改变。

关键词 染发剂，输卵管，豚鼠，鳞状上皮化生

 

THE EFFECT OF HAIRDYES ON UTERINE TUBE OF FEMALE GUINEA PIGS

Liu Jie, et al

Department of Public Health,Luzhou Medical College

Abstract Objective： To study the chronic toxicity of oxidiation hairdyes to uterine tube of guinea pigs. Methods： Guinea pigs were randomly divided into three groups:control group,hairdyes 50% group and 100%　group. Hairdyes were spreaded on the skin of guinea pigs for three months(one time per week), and at the end of the whole experiment, all guinea pigs were killed，dissected, and uterine tubes of female guinea pigs were observed under microscope after HE staining. Results： The weight of the guinea pigs was influenced by hair dyes, and squamous metaplasia was observed in part of the uterine tubes. Conclusion:The hairdyes can lead to pathological changes of the mucous membrane of the uterine tube in guinea pigs.

Key words Hairdyes； Uterine tube；Guinea pigs；Squamous metaplasia